HCID 57468713, compound → 4-{5-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyrimidin-2-yl]-[1,2,4]oxadiazol-3-yl}-pyridin-2-ylamine

HRID 1927998Notes

Reaction equation

HRID 1927998 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]([NH:10][OH:11])=[NH:9])[CH:5]=[CH:4][N:3]=1.[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[N:22]=[C:21]([C:29](O)=O)[N:20]=2)=[CH:15][CH:14]=1>>[Cl:12][C:13]1[CH:14]=[CH:15][C:16]([C:19]2[CH:24]=[C:23]([C:25]([F:27])([F:26])[F:28])[N:22]=[C:21]([C:29]3[O:11][N:10]=[C:8]([C:6]4[CH:5]=[CH:4][N:3]=[C:2]([NH2:1])[CH:7]=4)[N:9]=3)[N:20]=2)=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 57468713HCID 57468713, compoundHCID 1785133752-amino-N'-hydroxypyridine-4-carboximidamide

Product 1

HCID 247602864-{5-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyrimidin-2-yl]-[1,2,4]oxadiazol-3-yl}-pyridin-2-ylamine

Procedure

The title compound was prepared from 2-amino-N-hydroxy-pyridine-4-carboxamidine (example C.5) (0.11 g, 0.75 mmol) and 4-(4-chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-carboxylic acid (example D.1) (0.15 g, 0.5 mmol) according to the general procedure V. Obtained as an off-white solid (0.018 g, 9%). MS (ISP) 419.0 [(M+H)+]; mp 223.5° C.

Sources & evidence

ORD record
ord-222dbebc1bd744a89270a7a8f404bfe0
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

Loading…