HCID 57468714, compound → HCID 24760289, compound

HRID 1928002Notes

Reaction equation

HRID 1928002 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]([NH:10][OH:11])=[NH:9])[CH:5]=[CH:4][N:3]=1.[F:12][C:13]([F:34])([F:33])[C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[N:23]=[C:22]([C:30](O)=O)[N:21]=2)=[CH:16][CH:15]=1>>[F:29][C:26]([F:27])([F:28])[C:24]1[CH:25]=[C:20]([C:17]2[CH:18]=[CH:19][C:14]([C:13]([F:34])([F:33])[F:12])=[CH:15][CH:16]=2)[N:21]=[C:22]([C:30]2[O:11][N:10]=[C:8]([C:6]3[CH:5]=[CH:4][N:3]=[C:2]([NH2:1])[CH:7]=3)[N:9]=2)[N:23]=1

Participants

3

Reactant 2

HCID 57468714HCID 57468714, compoundHCID 1785133752-amino-N'-hydroxypyridine-4-carboximidamide

Product 1

HCID 24760289HCID 24760289, compound

Procedure

The title compound was prepared from 2-amino-N-hydroxy-pyridine-4-carboxamidine (example C.5) (0.11 g, 0.75 mmol) and 4-(4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-carboxylic acid (example D.2) (0.17 g, 0.5 mmol) according to the general procedure V. Obtained as an off-white solid (0.13 g, 57%). MS (ISP) 453.1 [(M+H)+]; mp 223.5° C.

Sources & evidence

ORD record
ord-9e42c1a16ddf4c3cbcfad313880d8bec
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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