HCID 57468714, compound → HCID 57468852, compound

HRID 1928006Notes

Reaction equation

HRID 1928006 reaction equation
[OH:1][NH:2][C:3](=[NH:14])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([S:10](=[O:13])(=[O:12])[NH2:11])[CH:5]=1.[F:15][C:16]([F:37])([F:36])[C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:28]=[C:27]([C:29]([F:32])([F:31])[F:30])[N:26]=[C:25]([C:33](O)=O)[N:24]=2)=[CH:19][CH:18]=1>>[F:32][C:29]([F:30])([F:31])[C:27]1[CH:28]=[C:23]([C:20]2[CH:21]=[CH:22][C:17]([C:16]([F:37])([F:36])[F:15])=[CH:18][CH:19]=2)[N:24]=[C:25]([C:33]2[O:1][N:2]=[C:3]([C:4]3[CH:5]=[C:6]([S:10]([NH2:11])(=[O:12])=[O:13])[CH:7]=[CH:8][CH:9]=3)[N:14]=2)[N:26]=1

Participants

3

Reactant 2

HCID 57468714HCID 57468714, compoundHCID 178513322HCID 178513322, compound

Product 1

HCID 57468852HCID 57468852, compound

Procedure

The title compound was prepared from N-hydroxy-3-sulfamoyl-benzamidine [CAS-No. 9000-88-7] (0.16 g, 0.75 mmol) and 4-(4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-carboxylic acid (example D.2) (0.17 g, 0.5 mmol) according to the general procedure V. Obtained as a white solid (0.099 g, 38%). MS (ISN) 514.1 [(M−H)−]; mp 204° C.

Sources & evidence

ORD record
ord-bf7deabc79ae4a5db42a9c31f3e877e3
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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