5-sulfamoylthiophene-2-carboxylic acid → HCID 57468853, compound

HRID 1928013Notes

Reaction equation

HRID 1928013 reaction equation
[OH:1][NH:2][C:3]([C:5]1[N:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[N:6]=1)=[NH:4].[S:25]([C:29]1[S:30][C:31]([C:34](O)=O)=[CH:32][CH:33]=1)(=[O:28])(=[O:27])[NH2:26]>>[F:14][C:11]([F:12])([F:13])[C:9]1[CH:8]=[C:7]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:22])[F:23])=[CH:17][CH:16]=2)[N:6]=[C:5]([C:3]2[N:4]=[C:34]([C:31]3[S:30][C:29]([S:25]([NH2:26])(=[O:28])=[O:27])=[CH:33][CH:32]=3)[O:1][N:2]=2)[N:10]=1

Participants

3

Reactant 2

HCID 3410665-sulfamoylthiophene-2-carboxylic acidHCID 178513396HCID 178513396, compound

Product 1

HCID 57468853HCID 57468853, compound

Procedure

The title compound was prepared from N-hydroxy-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-carboxamidine (example C.2) (0.176 g, 0.5 mmol) and commercially available 2-sulfamoyl-thiophene-5-carboxylic acid [CAS-No. 7353-87-9] (0.104 g, 0.5 mmol) according to the general procedure V. Obtained as a light yellow solid (0.12 g, 46%). MS (ISN) 520.1[(M−H)−]; mp 258.5° C.

Sources & evidence

ORD record
ord-e1bfdb251cc04e93960f6c58b1021a1c
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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