3-Pyridinylboronic acid → HCID 57468856, compound

HRID 1928024Notes

Reaction equation

HRID 1928024 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=3)[CH:11]=[C:10]([C:21]([F:24])([F:23])[F:22])[N:9]=2)[CH:5]=[CH:6][CH:7]=1.[N:25]1[CH:30]=[CH:29][CH:28]=[C:27](B(O)O)[CH:26]=1>>[Cl:20][C:17]1[CH:18]=[CH:19][C:14]([C:12]2[CH:11]=[C:10]([C:21]([F:24])([F:23])[F:22])[N:9]=[C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([C:27]4[CH:26]=[N:25][CH:30]=[CH:29][CH:28]=4)[CH:3]=3)[N:13]=2)=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 27343783-Pyridinylboronic acidHCID 57468728HCID 57468728, compound

Product 1

HCID 57468856HCID 57468856, compound

Procedure

The title compound was prepared from 2-(3-bromo-phenyl)-4-(4-chloro-phenyl)-6-trifluoromethyl-pyrimidine (example E.4) (0.21 g, 0.5 mmol) and commercially available 3-pyridineboronic acid (0.08 g, 0.65 mmol) according to the general procedure VI. Obtained as a white solid (0.12 g, 57%). MS (ISP) 412.3 [(M+H)+]; mp 162° C.

Sources & evidence

ORD record
ord-bbcdf07a5c5b4a31ba01e27e660c83ef
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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