HCID 57468715, compound → HCID 60209360, compound

HRID 1928026Notes

Reaction equation

HRID 1928026 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][OH:9])=[NH:7])=[CH:4][N:3]=1.[F:12][CH:13]([F:33])[C:14]1[N:19]=[C:18]([C:20](O)=O)[N:17]=[C:16]([C:23]2[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=2)[CH:15]=1>>[F:33][CH:13]([F:12])[C:14]1[CH:15]=[C:16]([C:23]2[CH:24]=[CH:25][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:27][CH:28]=2)[N:17]=[C:18]([C:20]2[O:9][N:8]=[C:6]([C:5]3[CH:10]=[CH:11][C:2]([NH2:1])=[N:3][CH:4]=3)[N:7]=2)[N:19]=1

Participants

3

Reactant 2

HCID 57468715HCID 57468715, compoundHCID 178513347HCID 178513347, compound

Product 1

HCID 60209360HCID 60209360, compound

Procedure

The title compound was prepared from 6-amino-N-hydroxy-nicotinamidine (example C.3) (0.15 g, 1.0 mmol) and 6-difluoromethyl-4-(4-trifluoromethyl-phenyl)-pyrimidine-2-carboxylic acid (example D.3) (0.16 g, 0.5 mmol) according to the general procedure V. Obtained as a light yellow solid (0.066 g, 30%). MS (ISP) 435.1 [(M+H)+]; mp 219° C.

Sources & evidence

ORD record
ord-230e869e40a146918e68f45b7eb4e38c
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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