4-Iodo-2,6-dimethylpyridine → HCID 57468863, compound

HRID 1928031Notes

Reaction equation

HRID 1928031 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:11]=[C:10]([C:18]3[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=3)[N:9]=2)[CH:5]=[CH:6][CH:7]=1.[CH3:28][C:29]1[CH:34]=[C:33](I)[CH:32]=[C:31]([CH3:36])[N:30]=1>>[CH3:28][C:29]1[CH:34]=[C:33]([C:2]2[CH:3]=[C:4]([C:8]3[N:13]=[C:12]([C:14]([F:15])([F:16])[F:17])[CH:11]=[C:10]([C:18]4[CH:19]=[CH:20][C:21]([C:24]([F:27])([F:25])[F:26])=[CH:22][CH:23]=4)[N:9]=3)[CH:5]=[CH:6][CH:7]=2)[CH:32]=[C:31]([CH3:36])[N:30]=1

Participants

3

Reactant 2

HCID 127591054-Iodo-2,6-dimethylpyridineHCID 574687272-(3-Bromo-phenyl)-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidine

Product 1

HCID 57468863HCID 57468863, compound

Procedure

The title compound was prepared from 2-(3-bromo-phenyl)-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine (example E.3) (0.45 g, 1.0 mmol) and 2,6-dimethyl-4-iodo-pyridine [CAS-No. 22282-67-3] (0.23 g, 1.0 mmol) according to the general procedure IVc. Obtained as a light yellow solid (0.057 g, 12%). MS (ISP) 474.2 [(M+H)+]; mp 159° C.

Sources & evidence

ORD record
ord-5b8f2e1926834857be94437d2062b64a
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

Loading…