3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine → HCID 24760215, compound

HRID 1928037Notes

Reaction equation

HRID 1928037 reaction equation
Br[C:2]1[N:3]=[CH:4][N:5]([C:7]2[N:12]=[C:11]([CH3:13])[CH:10]=[C:9]([C:14]3[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=3)[N:8]=2)[CH:6]=1.CC1(C)C(C)(C)OB([C:32]2[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=2)O1>>[CH3:13][C:11]1[CH:10]=[C:9]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)[N:8]=[C:7]([N:5]2[CH:6]=[C:2]([C:32]3[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=3)[N:3]=[CH:4]2)[N:12]=1

Participants

3

Reactant 2

HCID 27346563-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridineHCID 57468737HCID 57468737, compound

Product 1

HCID 24760215HCID 24760215, compound

Procedure

The title compound was prepared from 2-(4-bromo-imidazol-1-yl)-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine (example E.13) (0.31 g, 0.8 mmol) and commercially available 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (0.16 g, 0.8 mmol) according to the general procedure VI. Obtained as an off-white solid (0.012 g, 4%). MS (ISP) 382.3 [(M+H)+]; mp 208-210° C.

Sources & evidence

ORD record
ord-b497b9e25add4548a4178a6b9f683ca5
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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