3-Pyridinylboronic acid → 2-Methyl-6-(3-pyridin-3-yl-phenyl)-4-(4-trifluoromethyl-phenyl)-pyridine

HRID 1928049Notes

Reaction equation

HRID 1928049 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=3)[CH:11]=[C:10]([CH3:24])[N:9]=2)[CH:5]=[CH:6][CH:7]=1.[N:25]1[CH:30]=[CH:29][CH:28]=[C:27](B(O)O)[CH:26]=1>>[CH3:24][C:10]1[CH:11]=[C:12]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)[CH:13]=[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([C:27]3[CH:26]=[N:25][CH:30]=[CH:29][CH:28]=3)[CH:3]=2)[N:9]=1

Participants

3

Reactant 2

HCID 27343783-Pyridinylboronic acidHCID 574687452-(3-Bromo-phenyl)-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine

Product 1

HCID 574688662-Methyl-6-(3-pyridin-3-yl-phenyl)-4-(4-trifluoromethyl-phenyl)-pyridine

Procedure

The title compound was prepared from 2-(3-bromo-phenyl)-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine (example E.21) (0.392 g, 1.00 mmol) and commercially available 3-pyridineboronic acid (0.122 g, 0.99 mmol) according to the general procedure VI. Obtained as a white solid (0.080 g, 27%). MS (ISP) 391.1 [(M+H)+]; mp 89-106° C.

Sources & evidence

ORD record
ord-9f867aa8fed24defb974d2de9a32e3b5
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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