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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1928066Generated: October 30, 2026

Trifluoro-methanesulfonic acid 6-methyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl ester → 2-Methyl-6-(3-pyridin-4-yl-phenyl)-4-(4-trifluoromethyl-phenyl)-pyridine

https://huagongshe.com/reaction/1928066

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoro-methanesulfonic acid 6-methyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl esterHCID 57468647—
Reactant[3-(Pyridin-4-yl)phenyl]boronic acidHCID 60209378—
Product2-Methyl-6-(3-pyridin-4-yl-phenyl)-4-(4-trifluoromethyl-phenyl)-pyridineHCID 57468868—

Reaction Steps

The title compound was prepared from trifluoro-methanesulfonic acid 6-methyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl ester (example A.32) (0.250 g, 0.65 mmol) and 3-pyridin-4-yl-benzeneboronic acid [CAS-No. 337536-25-1] (0.143 g, 0.71 mmol) according to the general procedure VI. Obtained as a white solid (0.101 g, 40%). MS (ISP) 391.1 [(M+H)+]; mp 143-147° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08183262B2
Source datasetuspto-grants-2012_05
ORD IDord-9eb3d9ba53374fc38d3c96b9f2abd8d2
Source noteuspto-grants-2012_05