HCID 57468716, compound → HCID 60209381, compound

HRID 1928077Notes

Reaction equation

HRID 1928077 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][OH:9])=[NH:7])=[CH:4][N:3]=1.[CH2:12]([O:14][C:15]1[CH:16]=[C:17]([C:25]2[CH:30]=[C:29]([C:31]([F:34])([F:33])[F:32])[N:28]=[C:27]([C:35](O)=O)[N:26]=2)[CH:18]=[CH:19][C:20]=1[C:21]([F:24])([F:23])[F:22])[CH3:13]>>[CH2:12]([O:14][C:15]1[CH:16]=[C:17]([C:25]2[CH:30]=[C:29]([C:31]([F:33])([F:34])[F:32])[N:28]=[C:27]([C:35]3[O:9][N:8]=[C:6]([C:5]4[CH:10]=[CH:11][C:2]([NH2:1])=[N:3][CH:4]=4)[N:7]=3)[N:26]=2)[CH:18]=[CH:19][C:20]=1[C:21]([F:22])([F:23])[F:24])[CH3:13]

Participants

3

Reactant 2

HCID 57468716HCID 57468716, compoundHCID 178513347HCID 178513347, compound

Product 1

HCID 60209381HCID 60209381, compound

Procedure

The title compound was prepared from 6-amino-N-hydroxy-nicotinamidine (example C.3) (0.15 g, 1.0 mmol) and 4-(3-ethoxy-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-carboxylic acid (example D.4) (0.19 g, 0.5 mmol) according to the general procedure V. Obtained as a light yellow solid (0.076 g, 31%). MS (ISP) 497.3 [(M+H)+]; mp 216° C.

Sources & evidence

ORD record
ord-61bb3dc37b33404db867c93321ce8dd6
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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