5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine → HCID 86615454, compound

HRID 1928079Notes

Reaction equation

HRID 1928079 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[N:13]=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[C:16]([O:24][CH2:25][CH3:26])[CH:15]=3)[CH:11]=[C:10]([C:27]([F:30])([F:29])[F:28])[N:9]=2)[CH:5]=[CH:4][N:3]=1.[NH2:31][C:32]1[CH:37]=[CH:36][C:35](B2OC(C)(C)C(C)(C)O2)=[CH:34][N:33]=1>>[CH2:25]([O:24][C:16]1[CH:15]=[C:14]([C:12]2[CH:11]=[C:10]([C:27]([F:30])([F:29])[F:28])[N:9]=[C:8]([C:6]3[CH:5]=[CH:4][N:3]=[C:2]([C:35]4[CH:34]=[N:33][C:32]([NH2:31])=[CH:37][CH:36]=4)[CH:7]=3)[N:13]=2)[CH:19]=[CH:18][C:17]=1[C:20]([F:23])([F:22])[F:21])[CH3:26]

Participants

3

Reactant 2

HCID 27565555-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amineHCID 57468751HCID 57468751, compound

Product 1

HCID 86615454HCID 86615454, compound

Procedure

The title compound was prepared from 2-(2-chloro-pyridin-4-yl)-4-(3-ethoxy-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine (example E.33) (0.224 g, 0.5 mmol) and commercially available 2-amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (0.14 g, 0.65 mmol) according to the general procedure VI. Obtained as a light yellow solid (0.155 g, 61%). MS (ISP) 506.1 [(M+H)+]; mp 222° C.

Sources & evidence

ORD record
ord-e8c97c993be74f7b81d011864956d562
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

Loading…