5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine → 5-[6-Trifluoromethyl-4-(4-trifluoromethyl-phenyl)-[2,4']bipyrimidinyl-2'-yl]-pyridin-2-ylamine

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Reaction Steps

The title compound was prepared from 2′-chloro-6-trifluoromethyl-4-(4-trifluoromethyl-phenyl)-[2,4′]bipyrimidinyl (example E.42) (g, 0.5 mmol) and commercially available 2-amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (0.14 g, 0.65 mmol) according to the general procedure VI. Obtained as a light yellow solid (0.17 g, %). MS (ISP) 463.1 [(M+H)+]; mp 236.5° C.

Provenance & Evidence