2-Aminopyrimidine-5-boronic acid, pinacol ester → 5-[3-[4-(4-Chloro-phenyl)-6-methyl-pyrimidin-2-yl]-phenyl}-pyrimidin-2-ylamine

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Reaction Steps

The title compound was prepared from 2-(3-bromo-phenyl)-4-(4-chloro-phenyl)-6-methyl-pyrimidine (example E.44) (0.18 g, 0.5 mmol) and commercially available 2-amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine (0.14 g, 0.65 mmol) according to the general procedure VI. Obtained as a white solid (0.055 g, 29%). MS (ISP) 374.1 [(M+H)+]; mp 228° C.

Provenance & Evidence