N-hydroxy-4-sulfamoylbenzene-1-carboximidamide → HCID 57468877, compound

HRID 1928102Notes

Reaction equation

HRID 1928102 reaction equation
[OH:1][NH:2][C:3](=[NH:14])[C:4]1[CH:9]=[CH:8][C:7]([S:10](=[O:13])(=[O:12])[NH2:11])=[CH:6][CH:5]=1.[CH3:15][C:16]1[CH:21]=[C:20]([C:22]2[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=2)[N:19]=[C:18]([C:32](O)=O)[N:17]=1>>[CH3:15][C:16]1[CH:21]=[C:20]([C:22]2[CH:23]=[CH:24][C:25]([C:28]([F:31])([F:29])[F:30])=[CH:26][CH:27]=2)[N:19]=[C:18]([C:32]2[O:1][N:2]=[C:3]([C:4]3[CH:9]=[CH:8][C:7]([S:10]([NH2:11])(=[O:12])=[O:13])=[CH:6][CH:5]=3)[N:14]=2)[N:17]=1

Participants

3

Reactant 2

HCID 612025N-hydroxy-4-sulfamoylbenzene-1-carboximidamideHCID 57468720HCID 57468720, compound

Product 1

HCID 57468877HCID 57468877, compound

Procedure

The title compound was prepared from N-hydroxy-4-sulfamoyl-benzamidine [CAS-No. 4476-10-2] (0.12 g, 0.55 mmol) and 4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-carboxylic acid (example D.8) (0.104 g, 0.37 mmol) according to the general procedure V. Obtained as a white solid (0.025 g, 15%). MS (ISP) 462.4 [(M+H)+]; mp 326° C.

Sources & evidence

ORD record
ord-aa5711f9558e4a09a8593ef85d4cc8bc
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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