N-hydroxy-4-sulfamoylbenzene-1-carboximidamide → HCID 57468879, compound

HRID 1928111Notes

Reaction equation

HRID 1928111 reaction equation
[OH:1][NH:2][C:3](=[NH:14])[C:4]1[CH:9]=[CH:8][C:7]([S:10](=[O:13])(=[O:12])[NH2:11])=[CH:6][CH:5]=1.[CH3:15][C:16]1[CH:17]=[C:18]([C:26]2[CH:31]=[C:30]([C:32]([F:35])([F:34])[F:33])[N:29]=[C:28]([C:36](O)=O)[N:27]=2)[CH:19]=[CH:20][C:21]=1[C:22]([F:25])([F:24])[F:23]>>[CH3:15][C:16]1[CH:17]=[C:18]([C:26]2[CH:31]=[C:30]([C:32]([F:35])([F:33])[F:34])[N:29]=[C:28]([C:36]3[O:1][N:2]=[C:3]([C:4]4[CH:9]=[CH:8][C:7]([S:10]([NH2:11])(=[O:12])=[O:13])=[CH:6][CH:5]=4)[N:14]=3)[N:27]=2)[CH:19]=[CH:20][C:21]=1[C:22]([F:23])([F:24])[F:25]

Participants

3

Reactant 2

HCID 612025N-hydroxy-4-sulfamoylbenzene-1-carboximidamideHCID 57468721HCID 57468721, compound

Product 1

HCID 57468879HCID 57468879, compound

Procedure

The title compound was prepared from N-hydroxy-4-sulfamoyl-benzamidine [CAS-No. 4476-10-2] (0.14 g, 0.65 mmol) and 4-(3-methyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-carboxylic acid (example D.9) (0.175 g, 0.5 mmol) according to the general procedure V. Obtained as a white solid (0.147 g, 56%). MS (ISN) 528.3 [(M−H)−]; mp 261° C.

Sources & evidence

ORD record
ord-d2d3782f99f94ccd84a2f7b84bcd168b
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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