N-hydroxy-4-sulfamoylbenzene-1-carboximidamide → HCID 57468880, compound

HRID 1928118Notes

Reaction equation

HRID 1928118 reaction equation
[OH:1][NH:2][C:3](=[NH:14])[C:4]1[CH:9]=[CH:8][C:7]([S:10](=[O:13])(=[O:12])[NH2:11])=[CH:6][CH:5]=1.[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[C:26]([CH3:28])[N:25]=[C:24]([C:29](O)=O)[N:23]=2)=[CH:18][CH:17]=1>>[Cl:15][C:16]1[CH:17]=[CH:18][C:19]([C:22]2[CH:27]=[C:26]([CH3:28])[N:25]=[C:24]([C:29]3[O:1][N:2]=[C:3]([C:4]4[CH:9]=[CH:8][C:7]([S:10]([NH2:11])(=[O:12])=[O:13])=[CH:6][CH:5]=4)[N:14]=3)[N:23]=2)=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 612025N-hydroxy-4-sulfamoylbenzene-1-carboximidamideHCID 57468722HCID 57468722, compound

Product 1

HCID 57468880HCID 57468880, compound

Procedure

The title compound was prepared from N-hydroxy-4-sulfamoyl-benzamidine [CAS-No. 4476-10-2] (0.16 g, 0.75 mmol) and 4-(4-chloro-phenyl)-6-methyl-pyrimidine-2-carboxylic acid (example D.10) (0.124 g, 0.5 mmol) according to the general procedure V. Obtained as an off-white solid (0.032 g, 15%). MS (ISN) 426.1 [(M−H)−]; mp 297° C.

Sources & evidence

ORD record
ord-305c31de63004b9db2847b15bbedecc1
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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