2-Chloro-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidine → HCID 24760285, compound

HRID 1928129Notes

Reaction equation

HRID 1928129 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=2)[N:3]=1.[NH:22]1[CH:26]=[N:25][C:24]([C:27]2[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=2)=[N:23]1>>[N:29]1[CH:30]=[CH:31][CH:32]=[C:27]([C:24]2[N:25]=[CH:26][N:22]([C:2]3[N:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([C:12]4[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=4)[N:3]=3)[N:23]=2)[CH:28]=1

Participants

3

Reactant 2

HCID 574685992-Chloro-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidineHCID 178420775HCID 178420775, compound

Product 1

HCID 24760285HCID 24760285, compound

Procedure

The title compound was prepared from 2-chloro-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine (example A.2) (0.16 g, 0.5 mmol) and 3-(1H-[1,2,4]-triazol-3-yl)-pyridine [CAS-No. 23195-63-3] (0.075 g, 0.51 mmol) according to the general procedure IVa. Obtained as a light brown solid (0.095 g, 44%). MS (ISP) 437.3 [(M+H)+]; mp 190° C.

Sources & evidence

ORD record
ord-6a0a26abef124a6c88151d1a367ee0c5
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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