2-Aminopyrimidine-5-boronic acid, pinacol ester → HCID 60209420, compound

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Reaction Steps

The title compound was prepared from 2-(4-bromo-imidazol-1-yl)-4-isopropyl-6-(4-trifluoromethyl-phenyl)-pyrimidine (example E.66) (0.21 g, 0.5 mmol) and commercially available 2-amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine (0.14 g, 0.65 mmol) according to the general procedure VI. Obtained as an off-white solid (0.052 g, 24%). MS (ISP) 426.1 [(M+H)+]; mp 277° C.

Provenance & Evidence