HCID 57468723, compound → HCID 24760433, compound

HRID 1928265Notes

Reaction equation

HRID 1928265 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][OH:9])=[NH:7])=[CH:4][N:3]=1.[CH3:12][C:13]1[N:18]=[C:17]([C:19](O)=O)[CH:16]=[C:15]([C:22]2[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=2)[CH:14]=1>>[CH3:19][C:17]1[N:18]=[C:13]([C:12]2[O:9][N:8]=[C:6]([C:5]3[CH:10]=[CH:11][C:2]([NH2:1])=[N:3][CH:4]=3)[N:7]=2)[CH:14]=[C:15]([C:22]2[CH:23]=[CH:24][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:26][CH:27]=2)[CH:16]=1

Participants

3

Reactant 2

HCID 57468723HCID 57468723, compoundHCID 178513347HCID 178513347, compound

Product 1

HCID 24760433HCID 24760433, compound

Procedure

The title compound was prepared from 6-amino-N-hydroxy-nicotinamidine (example C.3) (0.113 g, 0.53 mmol) and 6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid (example D.11) (0.10 g, 0.36 mmol) according to the general procedure V. Obtained as an off-white solid (0.045 g, 31%). MS (ISP) 398.1 [(M+H)+]; mp 163° C.

Sources & evidence

ORD record
ord-ed56a4bd38f14cabb625fc2725357b4c
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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