2-Aminopyrimidine-5-boronic acid, pinacol ester → 4-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-[2,5']bipyrimidinyl-2'-ylamine

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Reaction Steps

The title compound was prepared from 2-chloro-4-[6-methyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-pyrimidine (example E.83) (0.40 g, 1.14 mmol) and commercially available 2-amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine (0.303 g, 1.37 mmol) according to the general procedure VI. Obtained as a white solid (0.050 g, 10%). MS (ISP) 409.2 [(M+H)+]; mp 264° C.

Provenance & Evidence