HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Aminosulphonyl)benzeneboronic acid → 3'-[6-Trifluoromethyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-biphenyl-3-sulfonic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Aminosulphonyl)benzeneboronic acid | HCID 44119323 | — |
| Reactant | 2-(3-Bromo-phenyl)-6-trifluoromethyl-4-(4-trifluoromethyl-phenyl)-pyridine | HCID 57468795 | — |
| Product | 3'-[6-Trifluoromethyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-biphenyl-3-sulfonic acid amide | HCID 57469009 | — |
Reaction Steps
The title compound was prepared from 2-(3-bromo-phenyl)-6-trifluoromethyl-4-(4-trifluoromethyl-phenyl)-pyridine (example E.81) (0.200 g, 0.448 mmol) and 3-sulfamoyl-benzeneboronic acid (example F.2) (0.100 g, 0.488 mmol) according to the general procedure VI. Obtained as a white solid (0.040 g, 15%). MS (ISP) 523.3 [(M+H)+]; mp 187° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183262B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-4277d4920f3444f8a164da3dfe6c9897 |
| Source note | uspto-grants-2012_05 |