Imidazole → HCID 57469011, compound

HRID 1928276Notes

Reaction equation

HRID 1928276 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=2)[CH:5]=[C:4]([CH3:16])[N:3]=1.[NH:17]1[CH:21]=[CH:20][N:19]=[CH:18]1>>[Cl:15][C:10]1[CH:9]=[C:8]([C:6]2[CH:5]=[C:4]([CH3:16])[N:3]=[C:2]([N:17]3[CH:21]=[CH:20][N:19]=[CH:18]3)[CH:7]=2)[CH:13]=[CH:12][C:11]=1[Cl:14]

Participants

3

Reactant 2

HCID 795ImidazoleHCID 57468674HCID 57468674, compound

Product 1

HCID 57469011HCID 57469011, compound

Procedure

The title compound was prepared from 2-chloro-4-(3,4-dichloro-phenyl)-6-methyl-pyridine (example A.51) (0.5 g, 0.8 mmol) and commercially available imidazole (0.112 g, 1.6 mmol) according to the general procedure IVa. Obtained as a white solid (0.060 g, 24%). MS (ISP) 304.0 [(M+H)+], 306 [(M+2+H)+] and 308 [(M+4+H)+]; mp 227° C.

Sources & evidence

ORD record
ord-296931b564a94f7d9e597c8a19bfb27e
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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