2-Aminopyrimidine-5-boronic acid, pinacol ester → 5-{3-[4-(3,4-Dichloro-phenyl)-6-methyl-pyridin-2-yl]-phenyl}-pyrimidin-2-ylamine

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Reaction Steps

The title compound was prepared from 2-(3-bromo-phenyl)-4-(3,4-dichloro-phenyl)-6-methyl-pyridine (example E.85) (0.20 g, 0.509 mmol) and commercially available 2-amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine (0.124 g, 0.56 mmol) according to the general procedure VI. Obtained as an off-white solid (0.100 g, 48%). MS (ISP) 407.2 [(M+H)+], 409.1 [(M+2+H)+] and 411 [(M+4+H)+]; mp 188° C.

Provenance & Evidence