HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[6-Methyl-4-(4-trifluoromethyl-phenyl)pyridin-2-yl]-benzeneboronic acid → 5-{3-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-phenyl}-pyridine-3-sulfonic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[6-Methyl-4-(4-trifluoromethyl-phenyl)pyridin-2-yl]-benzeneboronic acid | HCID 60209341 | — |
| Reactant | 5-bromo-N-(1-hydroxy-2-methylpropan-2-yl)pyridine-3-sulfonamide | HCID 60209343 | — |
| Product | 5-{3-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-phenyl}-pyridine-3-sulfonic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide | HCID 60209459 | — |
Reaction Steps
The title compound was prepared from 3-[6-methyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-benzeneboronic acid (example G.9) (0.20 g, 0.56 mmol) and 5-bromo-pyridine-3-sulfonic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide (example H.2) (0.173 g, 0.56 mmol) according to the general procedure VI. Obtained as a white solid (0.080 g, 26%). MS (ISP) 542.2 [(M+H)+]; mp 105° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183262B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-49889dd4d44d4468b4d36495878071de |
| Source note | uspto-grants-2012_05 |