3-(tert-Butylaminosulphonyl)benzeneboronic acid → N-tert-butyl-3-{4-[6-methyl-4-(4-trifluoromethylphenyl)-pyridin-2-yl]-pyrimidin-2-yl}-benzenesulfonamide

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Reaction Steps

The title compound was prepared from 2-chloro-4-[6-methyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-pyrimidine (example E.83) (0.5 g, 1.432 mmol) and commercially available 3-(tert-butylsulfamoyl)-benzeneboronic acid (0.404 g, 1.575 mmol) according to the general procedure VI. Obtained as a white solid (0.10 g, 13%) and additional off-white solid (0.48 g, 64%). MS (ISP) 527.2 [(M+H)+]; mp 218° C.

Provenance & Evidence