3-Bromobenzene-1-sulfonamide → HCID 57469022, compound

HRID 1928303Notes

Reaction equation

HRID 1928303 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[N:5]=[C:4]([C:18]2[CH:19]=[C:20](B(O)O)[CH:21]=[CH:22][CH:23]=2)[CH:3]=1.Br[C:28]1[CH:29]=[C:30]([S:34]([NH2:37])(=[O:36])=[O:35])[CH:31]=[CH:32][CH:33]=1>>[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[N:5]=[C:4]([C:18]2[CH:19]=[C:20]([C:28]3[CH:33]=[CH:32][CH:31]=[C:30]([S:34]([NH2:37])(=[O:36])=[O:35])[CH:29]=3)[CH:21]=[CH:22][CH:23]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 27347653-Bromobenzene-1-sulfonamideHCID 60209342HCID 60209342, compound

Product 1

HCID 57469022HCID 57469022, compound

Procedure

The title compound was prepared from 3-[4-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-benzeneboronic acid (example G.10) (0.407 g, 1.14 mmol) and commercially available 3-bromobenzenesulfonamide (177 mg, 1.14 mmol) according to the general procedure VI. Obtained as a white solid (0.052 g, 10%). MS (ISP) 469.4 [(M+H)+]; mp 200° C.

Sources & evidence

ORD record
ord-e1b45fc859524ed3865e9b35692546f1
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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