反应详情

To a stirred and cooled suspension of N-tert-butyl-3-[6-methyl-4-(4-trifluoromethyl-phenyl)-[2,4′]bipyridinyl-2′-yl]-benzenesulfonamide (example 287) (0.239 g, 0.455 mmol) in dichloromethane (1.5 mL) was added TFA (10 mL) and the reaction mixture was allowed to stir at room temperature for 16 h. The mixture was evaporated to dryness and saturated NaHCO3 solution (5 mL), diethyl ether and heptane were added. The mixture was stirred at room temperature for 1 h, the precipitate was collected by filtration, washed with water and heptane/diethyl ether and dried to yield the title compound as a white solid (0.200 g, 94%). MS (ISP) 470.3 [(M+H)+]; mp>250° C.

1. temperaturecooled
2. stirringto stir at room temperature for 16 h
3. customThe mixture was evaporated to dryness and saturated NaHCO3 solution (5 mL), diethyl ether and heptane
4. additionwere added
5. stirringThe mixture was stirred at room temperature for 1 h
6. filtrationthe precipitate was collected by filtration
7. washwashed with water and heptane/diethyl ether
8. customdried