HCID 68689159, compound → HCID 24760585, compound

Participants

Reaction Steps

A mixture of 6-methyl-2′-(3-nitro-phenyl)-4-(4-trifluoromethyl-phenyl)-[2,4′]bipyridinyl (example 306) (6.6 g, 15.15 mmol) in THF-MeOH 1:1 (300 mL) and 10% palladium on carbon (10 mol %) was hydrogenated (1 bar hydrogen) at 23° C. for 2 h. The catalyst was filtered off, washed with MeOH and the filtrate was completely evaporated totally to leave a crude product, which was triturated with diethyl ether and dried in HV to give the title compound as a light brown solid (6.0 g, 97%). MS (ISP) 406.3 [(M+H)+]; mp 162° C. (dec.).

Provenance & Evidence