Trifluoroacetic acid → HCID 68691467, compound

Participants

Reaction Conditions

Reaction Steps

To N-tert-butyl-3-[4-methyl-6-(4-trifluoromethyl-phenyl)-[2,4′]bipyridinyl-2′-yl]-benzenesulfonamide (example 297) (0.110 g, 0.19 mmol) was added TFA (6 mL) and the reaction mixture was stirred at 50° C. for 2 h. The mixture was evaporated to dryness and partitioned between EtOAc and saturated NaHCO3 solution, the organic layer was dried over Na2SO4. Removal of the solvent in vacuum left a crude product which was triturated with diethyl ether to give the title compound as a white solid (0.230 g, 98%). MS (ISP) 470.3 [(M+H)+]; mp 238° C.

Provenance & Evidence