3-Nitrophenylboronic Acid → HCID 68691292, compound

HRID 1928355Notes

Reaction equation

HRID 1928355 reaction equation
Br[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=3)[CH:11]=[C:10]([CH3:24])[N:9]=2)[CH:5]=[CH:4][CH:3]=1.[N+:25]([C:28]1[CH:29]=[C:30](B(O)O)[CH:31]=[CH:32][CH:33]=1)([O-:27])=[O:26]>>[CH3:24][C:10]1[N:9]=[C:8]([C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([C:32]3[CH:31]=[CH:30][CH:29]=[C:28]([N+:25]([O-:27])=[O:26])[CH:33]=3)[N:7]=2)[CH:13]=[C:12]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)[CH:11]=1

Participants

3

Reactant 2

HCID 16773-Nitrophenylboronic AcidHCID 866154406'-Bromo-6-methyl-4-(4-trifluoromethylphenyl)-[2,2']bipyridinyl

Product 1

HCID 68691292HCID 68691292, compound

Procedure

The 6-methyl-6′-(3-nitro-phenyl)-4-(4-trifluoromethyl-phenyl)-[2,2′]bipyridinyl was prepared from 6′-bromo-6-methyl-4-(4-trifluoromethyl-phenyl)-[2,2′]bipyridinyl (example E.26) (5.0 g, 12.71 mmol) and commercially available 3-nitrophenylboronic acid (2.547 g, 15.26 mmol) according to the general procedure VI. Obtained as a white solid (3.7 g, 66%). MS (ISP) 436.2 [(M+H)+].

Sources & evidence

ORD record
ord-d4927c1cba7644d6b1b3cc2271de5a95
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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