HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Aminosulphonyl)benzeneboronic acid → 4-[6-Methyl-4-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl-2'-yl]-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Aminosulphonyl)benzeneboronic acid | HCID 22391977 | — |
| Reactant | 2'-Chloro-6-methyl-4-(4-trifluoromethylphenyl)-[2,4']bipyridinyl | HCID 86615442 | — |
| Product | 4-[6-Methyl-4-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl-2'-yl]-benzenesulfonamide | HCID 24759947 | — |
Reaction Steps
The title compound was prepared from 2′-chloro-6-methyl-4-(4-trifluoromethyl-phenyl)-[2,4′]bipyridinyl (example E.28) (0.150 g, 0.430 mmol) and commercially available (4-aminosulfonylphenyl)boronic acid [CAS-No. 613660-87-0] (0.146 g, 0.516 mmol) according to the general procedure VI. Obtained as a white solid (0.075 g, 37%). MS (ISP) 470.3 [(M+H)+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183262B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-71d62074ffa64d6b91a8c806cd1e5ad9 |
| Source note | uspto-grants-2012_05 |