HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(tert-Butylaminosulphonyl)benzeneboronic acid → N-tert-Butyl-3-[4-(3-methoxy-4-trifluoromethyl-phenyl)-6-methyl-[2,4']bipyridinyl-2'-yl]-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(tert-Butylaminosulphonyl)benzeneboronic acid | HCID 44119538 | — |
| Reactant | 2'-Chloro-4-(3-methoxy-4-trifluoromethylphenyl)-6-methyl-[2,4']bipyridinyl | HCID 86615448 | — |
| Product | N-tert-Butyl-3-[4-(3-methoxy-4-trifluoromethyl-phenyl)-6-methyl-[2,4']bipyridinyl-2'-yl]-benzenesulfonamide | HCID 24759948 | — |
Reaction Steps
The title compound was prepared from 2′-chloro-4-(3-methoxy-4-trifluoromethyl-phenyl)-6-methyl-[2,4′]bipyridinyl (example E.99) (0.378 g, 1.0 mmol) and commercially available 3-(tert-butylsulfamoyl)-benzeneboronic acid (0.283 g, 1.1 mmol) according to the general procedure VI. Obtained as a white solid (0.390 g, 70%). MS (ISP) 556.5 [(M+H)+]; mp 189° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183262B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-0a31e868aede4aa4a2341835f34f0e8e |
| Source note | uspto-grants-2012_05 |