Hydroxyamine hydrochloride → HCID 68692740, compound

Participants

Reaction Steps

A mixture of the above described 2″-(2,5-dimethyl-pyrrol-1-yl)-6-methyl-4-(4-trifluoromethyl-phenyl)-[2,2′;6′,4″]terpyridine (470 mg, 0.969 mmol), hydroxylamine hydrochloride (337 mg, 4.849 mmol) 1.5 M NaOH-sol. (1.62 mL, 2.43 mmol) in 1-propanole (5 mL) was stirred at 120° C. for 3 h in a sealed tube. Cooled to rt, poured the reaction mixture directly on a silica gel column and chromatographed with EtOAc followed by trituration with diethyl ether/heptane to give the title compound (0.110 g, 27%) as a light yellow solid. MS (ISP) 407.3 [(M+H)+]; mp 160° C.

Provenance & Evidence