3-Nitrophenylboronic Acid → HCID 68694189, compound

HRID 1928387Notes

Reaction equation

HRID 1928387 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[C:12]([CH3:14])[CH:11]=[C:10]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=3)[N:9]=2)[CH:5]=[CH:4][N:3]=1.[N+:25]([C:28]1[CH:29]=[C:30](B(O)O)[CH:31]=[CH:32][CH:33]=1)([O-:27])=[O:26]>>[CH3:14][C:12]1[CH:11]=[C:10]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[N:9]=[C:8]([C:6]2[CH:5]=[CH:4][N:3]=[C:2]([C:32]3[CH:31]=[CH:30][CH:29]=[C:28]([N+:25]([O-:27])=[O:26])[CH:33]=3)[CH:7]=2)[CH:13]=1

Participants

3

Reactant 2

HCID 16773-Nitrophenylboronic AcidHCID 86615445HCID 86615445, compound

Product 1

HCID 68694189HCID 68694189, compound

Procedure

The 4-methyl-2′-(3-nitro-phenyl)-6-(4-trifluoromethyl-phenyl)-[2,4′]bipyridinyl was prepared from 2′-chloro-4-methyl-6-(4-trifluoromethyl-phenyl)-[2,4′]bipyridinyl (example E.94) (1.25 g, 3.6 mmol) and commercially available 3-nitrophenylboronic acid (0.718 g, 4.3 mmol) according to the general procedure VI. Obtained as a light brown solid (1.03 g, 66%). MS (ISP) 436.1 [(M+H)+]; mp 91° C.

Sources & evidence

ORD record
ord-660792889920491ea2ede682cf306c88
Source dataset
uspto-grants-2012_05
Patent number
US08183262B2

Reaction notes

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