HCID 71724478, compound → Sitagliptin

Participants

Reaction Steps

As used herein, Sitagliptin sulfate Form S2 refers to a crystalline Sitagliptin sulfate characterized by a powder XRD pattern with peaks at 9.3°, 9.7°, 15.2°, 15.6°, and 25.4°±0.2° 2θ. Sitagliptin sulfate Form S2 can be obtained, for example, by forming a solution of Sitagliptin base in acetonitrile; combining the solution with sulfuric acid to form a precipitate; and isolating the obtained precipitate; wherein, the sulfuric acid is used at a mol ratio of about 1:0.5 of Sitagliptin base to sulfuric acid, e.g., as indicated in PCT application No. PCT/US10/29098.

Provenance & Evidence