HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylmethanesulfonyl chloride → 5-((2-(1-(Benzylsulfonyl)piperidin-4-yl)-2H-1,2,3-triazol-4-yl)methoxy)-2-(1H-tetrazol-1-yl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylmethanesulfonyl chloride | HCID 74740 | — |
| Reactant | 5-((2-(piperidin-4-yl)-2H-1,2,3-triazol-4-yl)methoxy)-2-(1H-tetrazol-1-yl)pyridine hydrochloride | HCID 68746624 | — |
| Product | 5-((2-(1-(Benzylsulfonyl)piperidin-4-yl)-2H-1,2,3-triazol-4-yl)methoxy)-2-(1H-tetrazol-1-yl)pyridine | HCID 25174427 | — |
Reaction Steps
The title compound was synthesized using Intermediate 15 and phenylmethanesulfonyl chloride in a similar manner as described in Example 39. 1H NMR (DMSO-d6): δ 10.07 (1H, s), 8.41 (1H, d), 8.00 (1H, d), 7.96 (1H, s), 7.86 (1H, dd), 7.36 (5H, m), 5.35 (2H, s), 4.68 (1H, m), 4.43 (2H, s) 3.54 (2H, m), 2.99 (2H, m), 2.12 (2H, m), 1.91 (2H, m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183381B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-c54994d83354433a90546192ba0748ac |
| Source note | uspto-grants-2012_05 |