HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 4-hydroxy-2-methylpiperidine-1-carboxylate → tert-Butyl 4-(4-((2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 4-hydroxy-2-methylpiperidine-1-carboxylate | HCID 22181172 | — |
| Reactant | 1-(4-((2H-1,2,3-triazol-4-yl)methoxy)-3-fluorophenyl)-1H-tetrazole | HCID 57708434 | — |
| Product | tert-Butyl 4-(4-((2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidine-1-carboxylate | HCID 57708424 | — |
Reaction Steps
The title compound was synthesized from tert-butyl 4-hydroxy-2-methylpiperidine-1-carboxylate and 1-(4-((2H-1,2,3-triazol-4-yl)methoxy)-3-fluorophenyl)-1H-tetrazole (Intermediate 16) in a manner similar to that described in Example 48, Step 4. The title compound was isolated as a mixture of four stereoisomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183381B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-cfe1e14fc7c946808f8cd6ed56e54c58 |
| Source note | uspto-grants-2012_05 |