tert-Butyl 4-(4-((2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidine-1-carboxylate → 4-(4-((2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidine hydrochloride

HRID 1928629Notes

Reaction equation

HRID 1928629 reaction equation
[F:1][C:2]1[CH:28]=[C:27]([N:29]2[CH:33]=[N:32][N:31]=[N:30]2)[CH:26]=[CH:25][C:3]=1[O:4][CH2:5][C:6]1[CH:10]=[N:9][N:8]([CH:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH:13]([CH3:24])[CH2:12]2)[N:7]=1.[ClH:34].FC1C=C(S(C)(=O)=O)C=CC=1OCC1N=CN(C2CCNCC2)N=1>>[ClH:34].[F:1][C:2]1[CH:28]=[C:27]([N:29]2[CH:33]=[N:32][N:31]=[N:30]2)[CH:26]=[CH:25][C:3]=1[O:4][CH2:5][C:6]1[CH:10]=[N:9][N:8]([CH:11]2[CH2:16][CH2:15][NH:14][CH:13]([CH3:24])[CH2:12]2)[N:7]=1

Participants

3

Reactant 2

HCID 57708424tert-Butyl 4-(4-((2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidine-1-carboxylateHCID 687280424-[3-(2-Fluoro-4-methanesulfonyl-phenoxymethyl)-[1,2,4]triazol-1-yl]-piperidine hydrochloride

Product 1

HCID 687466114-(4-((2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidine hydrochloride

Procedure

The title compound was synthesized from tert-butyl 4-(4-((2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidine-1-carboxylate in a manner similar to that described in Intermediate 6. The title compound was isolated as a mixture of four stereoisomers.

Sources & evidence

ORD record
ord-46b309da1a96480ea2016eb646b37dbb
Source dataset
uspto-grants-2012_05
Patent number
US08183381B2

Reaction notes

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