4-Chloro-2-iodopyrimidine → 5-Chloro-2-(4-(4-((2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidin-1-yl)pyrimidine

HRID 1928630Notes

Reaction equation

HRID 1928630 reaction equation
[ClH:1].[F:2][C:3]1[CH:22]=[C:21]([N:23]2[CH:27]=[N:26][N:25]=[N:24]2)[CH:20]=[CH:19][C:4]=1[O:5][CH2:6][C:7]1[CH:11]=[N:10][N:9]([CH:12]2[CH2:17][CH2:16][NH:15][CH:14]([CH3:18])[CH2:13]2)[N:8]=1.Cl[C:29]1[N:34]=[C:33](I)[N:32]=[CH:31][CH:30]=1>>[Cl:1][C:30]1[CH:31]=[N:32][C:33]([N:15]2[CH2:16][CH2:17][CH:12]([N:9]3[N:8]=[C:7]([CH2:6][O:5][C:4]4[CH:19]=[CH:20][C:21]([N:23]5[CH:27]=[N:26][N:25]=[N:24]5)=[CH:22][C:3]=4[F:2])[CH:11]=[N:10]3)[CH2:13][CH:14]2[CH3:18])=[N:34][CH:29]=1

Participants

3

Reactant 2

HCID 539498604-Chloro-2-iodopyrimidineHCID 687466114-(4-((2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidine hydrochloride

Product 1

HCID 251750875-Chloro-2-(4-(4-((2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidin-1-yl)pyrimidine

Procedure

The title compound was synthesized from 4-(4-((2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidine hydrochloride and 6-chloro-2-iodopyrimidine in a manner similar to that described in Example 9. The title compound was isolated as a mixture of four stereoisomers.

Sources & evidence

ORD record
ord-d2417a421b244220917e54247ea32c39
Source dataset
uspto-grants-2012_05
Patent number
US08183381B2

Reaction notes

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