HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphosgene → (1S,4S)-2-Oxa-5-aza-bicyclo[2.2.1]heptane-5-carboxylic acid [2-((R)-indan-1-ylamino)-quinolin-6-yl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | (1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane hydrobromide | HCID 11159293 | — |
| Reactant | (R)-N2-Indan-1-yl-quinoline-2,6-diamine | HCID 57860958 | — |
| Product | (1S,4S)-2-Oxa-5-aza-bicyclo[2.2.1]heptane-5-carboxylic acid [2-((R)-indan-1-ylamino)-quinolin-6-yl]-amide | HCID 86634162 | — |
Reaction Steps
The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, (1S,4S)-2-oxa-5-aza-bicyclo[2.2.1]heptane and (R)—N2-indan-1-yl-quinoline-2,6-diamine; MS: m/e=401.6 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183380B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-d5ea96ebc67f4f54a6d0d7c781646c6e |
| Source note | uspto-grants-2012_05 |