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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1928737Generated: November 1, 2026

Triphosgene → 1-[2-((R)-Indan-1-ylamino)-quinolin-6-yl]-3-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-urea

https://huagongshe.com/reaction/1928737

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTriphosgeneHCID 94429—
ReactantHCID 10820667HCID 10820667—
Reactant(R)-N2-Indan-1-yl-quinoline-2,6-diamineHCID 57860958—
Product1-[2-((R)-Indan-1-ylamino)-quinolin-6-yl]-3-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-ureaHCID 44218098—

Reaction Steps

The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, 2-(tetrahydro-pyran-2-yloxy)-ethylamine and (R)—N2-indan-1-yl-quinoline-2,6-diamine; MS: m/e=446.6 (M+H+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08183380B2
Source datasetuspto-grants-2012_05
ORD IDord-1cb4b0c3ca7a44a3ad2ff82ce81a9418
Source noteuspto-grants-2012_05