Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → HCID 44217942, compound

Participants

Reaction Conditions

Reaction Steps

4-(Tetrahydro-pyran-2-yloxymethyl)-piperidine-1-carboxylic acid [2-((R)-indan-1-ylamino)-quinolin-6-yl]-amide (0.070 g) was dissolved in methanol (1 mL). Pyridinium toluene-4-sulfonate (11.0 mg) was added and the reaction mixture stirred at 55° C. for 1 h. The reaction mixtures was diluted with water and extracted with ethyl acetate. The combined organic phases were dried on sodium sulfate, evaporated and the residue was subjected to column chromatography (silica gel, dichloro methane:methanol gradient=100:0→90:10) to yield the title compound (35 mg; 60%) as an off-white solid; MS: m/e=416.7 (M+H+).

Provenance & Evidence