HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1928749Generated: October 29, 2026
Triethylamine → Tert-butyl {1-[2-(methylsulfanyl)ethyl]piperidin-4-yl}carbamate
https://huagongshe.com/reaction/1928749
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Chloroethyl methyl sulfide | HCID 10965 | — |
| Reactant | 4-(N-Boc-amino)piperidine | HCID 723833 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Tert-butyl {1-[2-(methylsulfanyl)ethyl]piperidin-4-yl}carbamate | HCID 49817086 | — |
Reaction Steps
Piperidin-4-yl-carbamic acid tert-butyl ester (0.70 g, 3.0 mmol), triethylamine (1.46 mL, 10 mmol) and 2-chlorethyl-methylsulfide (0.39 g, 3.0 mmol) were dissolved in methanol (10 mL) and stirred for 16 h at 50° C. Then the solvent was removed and the residue subjected to column chromatography (silica gel, heptane:ethyl acetate gradient=1:1→0:1). [1-(2-Methylsulfanyl-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester was obtained as a light yellow solid (0.46 g, 48%); MS: m/e=275.5 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08183380B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-98dcaae06bb14708a0c3991db097a8c7 |
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| Source note | uspto-grants-2012_05 |
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