Hydrochloride methanol → 1-[2-(Methylthio)ethyl]piperidin-4-amine dihydrochloride

HRID 1928750Notes

Reaction equation

C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][S:16][CH3:17])[CH2:10][CH2:9]1)(C)(C)C.[ClH:19].CO>>[ClH:19].[ClH:19].[CH3:17][S:16][CH2:15][CH2:14][N:11]1[CH2:10][CH2:9][CH:8]([NH2:7])[CH2:13][CH2:12]1

Participants

Reactant 2

HCID 21893726Hydrochloride methanol

HCID 49817086Tert-butyl {1-[2-(methylsulfanyl)ethyl]piperidin-4-yl}carbamate

Product 1

HCID 509443381-[2-(Methylthio)ethyl]piperidin-4-amine dihydrochloride

Conditions

Temperature: 40 °C

Procedure

[1-(2-Methylsulfanyl-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester (0.35 g, 1.0 mmol) was dissolved in HCl/Methanol (2.5M, 4 mL) and stirred for 1.5 h at 40° C. After evaporation of the solvent and drying under high vacuum, 1-(2-methylsulfanyl-ethyl)-piperidin-4-ylamine dihydrochloride was obtained as an off-white solid (0.22 g, 100%); MS: m/e=175.5 (M+H+).

Workup

customAfter evaporation of the solvent
customdrying under high vacuum

Sources & evidence

ORD record: ord-fa2c9de673ba48d18e2b1ed92ed4530a
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08183380B2

Reaction notes

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