HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphosgene → 1-[2-((R)-Indan-1-ylamino)-quinolin-6-yl]-3-[1-(2-methylsulfanyl-ethyl)-piperidin-4-yl]-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | 1-[2-(Methylthio)ethyl]piperidin-4-amine dihydrochloride | HCID 50944338 | — |
| Reactant | (R)-N2-Indan-1-yl-quinoline-2,6-diamine | HCID 57860958 | — |
| Product | 1-[2-((R)-Indan-1-ylamino)-quinolin-6-yl]-3-[1-(2-methylsulfanyl-ethyl)-piperidin-4-yl]-urea | HCID 44217776 | — |
Reaction Steps
The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, 1-(2-methylsulfanyl-ethyl)-piperidin-4-ylamine dihydrochloride and (R)—N2-indan-1-yl-quinoline-2,6-diamine; MS: m/e=476.7 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183380B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-097234b2fea6413fa1886409bd2d1e63 |
| Source note | uspto-grants-2012_05 |