HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphosgene → Rac-1-[2-(7-methoxy-indan-1-ylamino)-quinolin-6-yl]-3-[1-(3,3,3-trifluoro-propionyl)-piperidin-4-yl]-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | 1-(4-Aminopiperidin-1-yl)-3,3,3-trifluoropropan-1-one hydrochloride | HCID 47003381 | — |
| Reactant | Rac-n2-(7-methoxy-indan-1-yl)-quinoline-2,6-diamine | HCID 57860964 | — |
| Product | Rac-1-[2-(7-methoxy-indan-1-ylamino)-quinolin-6-yl]-3-[1-(3,3,3-trifluoro-propionyl)-piperidin-4-yl]-urea | HCID 44217625 | — |
Reaction Steps
The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, 1-(4-amino-piperidin-1-yl)-3,3,3-trifluoro-propan-1-one hydrochloride and rac-N2-(7-methoxy-indan-1-yl)-quinoline-2,6-diamine (Example 172); MS: m/e=542.8 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183380B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-c935c809523f451f93212108c233aa2b |
| Source note | uspto-grants-2012_05 |