HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphosgene → Rac-1-[1-(2-fluoro-ethyl)-piperidin-4-yl]-3-[2-(8-methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylamino)-quinolin-6-yl]-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | 1-(2-Fluoroethyl)piperidin-4-amine | HCID 16748092 | — |
| Reactant | Rac-n2-(8-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-quinoline-2,6-diamine | HCID 57860959 | — |
| Product | Rac-1-[1-(2-fluoro-ethyl)-piperidin-4-yl]-3-[2-(8-methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylamino)-quinolin-6-yl]-urea | HCID 87523350 | — |
Reaction Steps
The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, 1-(2-fluoroethyl)-piperidin-4-ylamine and rac-N2-(8-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-quinoline-2,6-diamine; MS: m/e=492.5 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08183380B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-2c41efdd50f64b8cb586413121ad7132 |
| Source note | uspto-grants-2012_05 |