反应详情

Rac-7-methoxy-indan-1-ylamine hydrochloride (2.20 g, 0.011 mmol) was dissolved in acetic acid (100 mL). After cooling to 0° C. sulfuryl chloride (1.88 mL, 0.23 mmol) was slowly added and the reaction mixture was stirred for 16 h at ambient temperature. Then the solvent was evaporated and the residue was taken up in isopropanol. Thereby a precipitate formed which was isolated and dried on high vacuum to yield rac-4,6-dichloro-7-methoxy-indan-1-ylamine (2.0 g, 68%) as a white solid; MS: m/e=269.6 (M+H+).

1. additionwas slowly added
2. customThen the solvent was evaporated
3. customThereby a precipitate formed which
4. customwas isolated
5. customdried on high vacuum