Hydrochloride methanol → HCID 44218871, compound

HRID 1928771Notes

Reaction equation

C(OC(=O)[NH:7][S:8]([NH:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[N:18]=[C:17]([NH:22][C@H:23]1[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[CH2:25][CH2:24]1)[CH:16]=[CH:15]2)(=[O:10])=[O:9])(C)(C)C.[ClH:33].CO>>[ClH:33].[C@H:23]1([NH:22][C:17]2[CH:16]=[CH:15][C:14]3[C:19](=[CH:20][CH:21]=[C:12]([NH:11][S:8]([NH2:7])(=[O:10])=[O:9])[CH:13]=3)[N:18]=2)[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH2:25][CH2:24]1

Participants

Reactant 2

HCID 21893726Hydrochloride methanol

HCID 57860968HCID 57860968, compound

Product 1

HCID 44218871HCID 44218871, compound

Conditions

Temperature: 60 °C

Procedure

tert-butyl[({2-[(1R)-2,3-dihydro-1H-inden-1-ylamino]quinolin-6-yl}amino)sulfonyl]carbamate (0.012 mg, 0.026 mmol) was dissolved in HCl/methanol (2.5 M, 1.0 mL) and stirred for 2 h at 60° C. Upon evaporation of the solvent and drying on high vacuum the title compound was obtained as a yellow solid (8 mg; 80%); MS: m/e=392.0 (M+H+).

Workup

customUpon evaporation of the solvent
dry with materialdrying on high vacuum the title compound
customwas obtained as a yellow solid (8 mg; 80%)

Sources & evidence

ORD record: ord-94e72d21d4294fbda3efa97876cd418b
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08183380B2

Reaction notes

Loading…